Rent A Car and Drive From Chicago to St. Louis
Are you looking to go to St. Louis? In these uncertain times, many of us are rethinking the way we travel and the added safety precautions that must be considered along the way. A rental car from a neighborhood Enterprise location in Chicago can alleviate many of these concerns, so you can get to St. Louis safely.
Drive time: approx. 4.5 hour (Driving Directions)
Distance: approx. 298 miles
COVID-19 Car Rental Resources
From our Complete Clean Pledge to curbside pickup options, we're here to help you get back on the road again.
COVID-19 Car Rental FAQs
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Check our COVID-19 FAQs for information on hours of operation, reservations and steps we're taking to keep employees and customers safe.
COVID-19 FAQsPlanning a Road Trip During COVID-19
Are you thinking about taking a road trip during COVID-19? Check out our tips and resources to consider before you leave.
Plan Your TripComplete Clean Pledge
Learn about our commitment to protecting the well-being of customers and employees, including our Complete Clean Pledge.
Complete Clean Pledge DetailsChicago Drives and Road Trips
Drive From Chicago to Grand Rapids
Looking to go from Chicago to Grand Rapids? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From Chicago to South Haven
Looking to go from Chicago to South Haven? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From Chicago to Lake Geneva
Looking to go from Chicago to Lake Geneva? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From Chicago to Detroit
Looking to go from Chicago to Detroit? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From Chicago to Milwaukee
Looking to go from Chicago to Milwaukee? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From Chicago to Indiana Dunes
Looking to go from Chicago to Indiana Dunes? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From Chicago to St. Louis
Looking to go from Chicago to St. Louis? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Road Trip from Chicago to Denver
Take a trip from the Windy City to the Mile High City with Enterprise Rent-A-Car. Find some unique places to stop along the way!
Drive from Chicago to New Orleans
Start in Chicago and end in New Orleans with this road trip itinerary. Enjoy stops in St. Louis, Memphis, and Jackson along the way to maximize the drive.
Drive From St. Louis to Little Rock
Looking to go from St. Louis to Little Rock? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to Indianapolis
Looking to go from St. Louis to Indianapolis? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to the Ozarks
Looking to go from St. Louis to the Ozarks? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to Milwaukee
Looking to go from St. Louis to Milwaukee? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to Pensacola
Looking to go from St. Louis to Pensacola? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to Kansas City
Looking to go from St. Louis to Kansas City? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to Chicago
Looking to go from St. Louis to Chicago? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From St. Louis to Nashville
Looking to go from St. Louis to Nashville? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive from Chicago to New Orleans
Start in Chicago and end in New Orleans with this road trip itinerary. Enjoy stops in St. Louis, Memphis, and Jackson along the way to maximize the drive.
Road Trip from Chicago to Denver
Take a trip from the Windy City to the Mile High City with Enterprise Rent-A-Car. Find some unique places to stop along the way!
Drive From Chicago to Grand Rapids
Looking to go from Chicago to Grand Rapids? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From Chicago to St. Louis
Looking to go from Chicago to St. Louis? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From Chicago to South Haven
Looking to go from Chicago to South Haven? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From Chicago to Lake Geneva
Looking to go from Chicago to Lake Geneva? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From Chicago to Detroit
Looking to go from Chicago to Detroit? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From Chicago to Indiana Dunes
Looking to go from Chicago to Indiana Dunes? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Drive From Chicago to Milwaukee
Looking to go from Chicago to Milwaukee? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.
Popular Rental Vehicle Types
SUVs
Trucks
Vans
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